The Siege of Genoa took place on January 1950 and saw the defeat of Italy's military and United European Defense forces as they were overwhelmed by the sheer number and tremendous durability of the Chimera. This gave the Chimera the title of "The Deathless Plague". Due to this, Italian soldiers were psychologically terrified by the Chimera's tenacity and appearance, and suffered a major blow to their morale which contributed to Genoa's downfall. It had been reported that hundreds of Italian soldiers commited suicide to avoid fighting the Chimera or worse, turning into them.
In the aftermath of the siege, Italy was laid in ruins and making it one of the last nations in mainland Europe to fall to the Chimera.